The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Case report
Transmission of dengue virus from deceased donors to solid organ transplant recipients: case report and literature review
Fernando Rossoa,b,c,, , Juan C. Pinedab, Ana M. Sanzc, Jorge A. Cedanoc, Luis A. Caicedod
a Fundación Valle del Lili, Departamento de Medicina Interna – Enfermedades Infecciosas, Cali, Colombia
b Universidad Icesi, Facultad de Ciencias de la Salud, Cali, Colombia
c Fundación Valle del Lili, Centro de Investigaciones Clínicas, Cali, Colombia
d Fundación Valle del Lili, División de Cirugía de Trasplante, Cali, Colombia
Received 27 October 2017, Accepted 01 January 2018

Dengue fever is a vector-transmitted viral infection. Non-vectorial forms of transmission can occur through organ transplantation. We reviewed medical records of donors and recipients with suspected dengue in the first post-transplant week. We used serologic and molecular analysis to confirm the infection. Herein, we describe four cases of dengue virus transmission through solid organ transplantation. The recipients had positive serology and RT-PCR. Infection in donors was detected through serology. All cases presented with fever within the first week after transplantation. There were no fatal cases. After these cases, we implemented dengue screening with NS1 antigen detection in donors during dengue outbreaks, and no new cases were detected. In the literature review, additional cases had been published through August 2017. Transmission of Dengue virus can occur through organ donation. In endemic regions, it is important to suspect and screen for dengue in febrile and thrombocytopenic recipients in the postoperative period.

Dengue virus, Transmission, Solid organ transplantation, Screening