The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2018;22:85-91 - Vol. 22 Num.2 DOI: 10.1016/j.bjid.2018.02.001
Original article
Seroprevalence of hepatitis E virus in chronic hepatitis C in Brazil
Guilherme Bricksa,, , Jorge Figueiredo Senisea, Henrique Pott Juniora, Giuliano Grandia, Amanda Passarinia, Débora Bellini Caldeiraa, Dimas Carnaúba Juniorb, Hamilton Antonio Bonilha de Moraesc, Celso Franscisco Hernandes Granatoa, Adauto Casteloa
a Universidade Federal de São Paulo, Departamento de Medicina, Divisão de Doenças Infecciosas, São Paulo, SP, Brazil
b Hospital de Transplante Euryclides Jesus Zerbini, Ambulatório de Doenças Infecciosas, São Paulo, SP, Brazil
c Instituto de Vacinação e Infectologia de Piracicaba, Piracicaba, SP, Brazil
Received 28 September 2017, Accepted 02 February 2018
Abstract
Background and aims

Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality. The seroprevalence of hepatitis E virus in patients with chronic hepatitis C in Brazil is unknown. This study aims to estimate the seroprevalence of hepatitis E virus in patients with chronic hepatitis C and to describe associated risk factors.

Methods

A total of 618 patients chronically infected with hepatitis C virus from three reference centers of São Paulo, Brazil were included. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA).

Results

Out of the 618 patients tested, 10.2% turned out positive for anti-HEV IgG (95% CI 8.0–12.8%). Higher seroprevalence was found independently associated with age over 60 years (OR=2.04; p=0.02) and previous contact with pigs (OR=1.99; p=0.03).

Conclusions

Patients with chronic hepatitis C are under risk of hepatitis E virus superinfection in São Paulo. Contact with pigs is a risk factor for the infection, suggesting a possible zoonosis with oral transmission.

Keywords
Hepatitis E virus, Hepatitis C virus, Brazil, Seroprevalence
Braz J Infect Dis 2018;22:85-91 - Vol. 22 Num.2 DOI: 10.1016/j.bjid.2018.02.001