The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2018;22:150-2 - Vol. 22 Num.2 DOI: 10.1016/j.bjid.2018.02.003
Brief communication
Seronegativity to polio viruses among previously immunized adult candidates to solid organ transplantation
Luciana Gomes Pedro Brandãoa,, , Pedro Emmanuel Alvarenga Americano do Brasilb, Silas de Souza Oliveirac, Edson Elias da Silvac, Guilherme Santoro Lopesd
a Instituto Nacional de Infectologia Evandro Chagas (Fiocruz), Laboratório de Pesquisa em Imunizações e Vigilância em Saúde (LIVS), Centro de Referência para Imunobiológicos Especiais, Rio de Janeiro, RJ, Brazil
b Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa em Imunizações e Vigilância em Saúde (LIVS), Rio de Janeiro, RJ, Brazil
c Instituto Oswaldo Cruz (Fiocruz), Laboratório de Enterovírus, Rio de Janeiro, RJ, Brazil
d Universidade Federal do Rio de Janeiro, Departamento de Medicina Preventiva, Rio de Janeiro, RJ, Brazil
Received 24 October 2017, Accepted 09 February 2018
Abstract

In the current effort to eliminate polio from the world, it is important to recognize and vaccinate susceptible groups, especially immunocompromised patients living in countries where attenuated polio vaccine is still used. In this report, we describe the frequency of protective antibodies in a small sample of adult SOT candidates in whom previous vaccination could be ascertained. Patients included in this report were selected among the participants of an ongoing prospective study carried out at the Reference Center for Special Immunobiologicals of the Evandro Chagas National Institute of Infectious Diseases in Rio de Janeiro, Brazil. Among the first 100 patients enrolled in this study, only seven adult SOT candidates had proven polio vaccination at childhood. Three of these seven patients (43%) had no protective antibody titers to one or more poliovirus subtype before solid organ transplant. Proven childhood vaccination against polio does not reliably provide lifelong protective antibody titers for adult SOT candidates and should not be used as a criterion to analyze the need for vaccination in this population.

Keywords
Poliomyelitis, Immunity, Solid organ transplantation
Braz J Infect Dis 2018;22:150-2 - Vol. 22 Num.2 DOI: 10.1016/j.bjid.2018.02.003