The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Brief communication
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age
Alexandre Casimiro de Macedoa, José Evandro Cunhaa, Juliana Navarro Ueda Yaochitea, Clodis Maria Tavaresb, Aparecida Tiemi Nagao-Diasa,,
a Universidade Federal do Ceará (UFC), Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Fortaleza, CE, Brazil
b Universidade Federal de Alagoas, Faculdade de Enfermagem e Farmácia (ESENFAR), Maceio, AL, Brazil
Received 03 January 2017, Accepted 11 May 2017
Abstract

Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4–16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State – Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the present work that salivary anti-PGL IgA and IgM are important biomarkers to be used for identifying communities with probable active transmission of M. leprae.

Keywords
Leprosy, Salivary antibodies, Phenolic glycolipid-1 antigen, Mycobacterium leprae