The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Original article
Retrospective evaluation of the clinical characteristics associated with Corynebacterium species bacteremia
Mitsuru Yanaia,, , Maiko Ogasawasaa, Yuta Hayashia, Kiyozumi Suzukia, Hiromichi Takahashib, Atsushi Satomurab
a Nihon University School of Medicine, Department of Internal Medicine, Division of General Medicine, Tokyo, Japan
b Nihon University School of Medicine, Department of Pathology and Mircobiology, Division of Laboratory Medicine, Tokyo, Japan
Received 15 September 2017, Accepted 21 December 2017
Abstract
Objectives

Corynebacterium spp. are becoming recognized as pathogens that potentially cause various infections. We aimed to evaluate the clinical characteristics associated with Corynebacterium spp. bacteremia.

Patients and methods

We retrospectively reviewed the medical records of all adult patients who had positive blood cultures for Corynebacterium spp. in a single university hospital between January 2014 and December 2016. Patients were divided into a bacteremia group and a contamination group based on microbiological test results and clinical characteristics. Patients’ characteristics, antimicrobial susceptibility of isolated species, antimicrobials administered, and patient outcomes were evaluated.

Results

Corynebacterium spp. were isolated from blood samples of 63 patients; Corynebacterium striatum was the predominant isolate. Twenty-eight patients were determined to have bacteremia. Younger age (p=0.023), shorter time to positivity (p=0.006), longer hospital stay (p=0.009), and presence of an indwelling vascular catheter (p=0.002) were observed more often in the bacteremia group compared to the contamination group. The source of infection in most patients with bacteremia was an intravenous catheter. All tested strains were susceptible to vancomycin. Four of the 27 patients with bacteremia died, despite administration of appropriate antimicrobial therapy.

Conclusions

We found that younger age, shorter time to positivity, and presence of an indwelling catheter were related to bacteremia caused by Corynebacterium spp. Appropriate antimicrobials should be administered once Corynebacterium spp. are isolated from the blood and bacteremia is suspected.

Keywords
Corynebacterium species, Blood culture, Bloodstream infection, Contamination