The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2018;22:137-41 - Vol. 22 Num.2 DOI: 10.1016/j.bjid.2018.02.005
Review article
Prevalence of Guillain-Barré syndrome among Zika virus infected cases: a systematic review and meta-analysis
Ludovica Barbia, Antonio Victor Campos Coelhob, Luiz Cláudio Arraes de Alencarc,d, Sergio Crovellae,f,,
a King's College London, Department of Global Health and Social Medicine, London, United Kingdom
b Universidade Federal de Pernambuco, Departamento de Genética, Recife, PE, Brazil
c Universidade Federal de Pernambuco, Departamento de Medicina Tropical, Recife, PE, Brazil
d Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, Brazil
e Scientific Institute for Research, Hospitalization and Care (IRCCS), Institute for Maternal and Child Health, Trieste, Italy
f University of Trieste, Department of Developmental and Reproductive Sciences, Genetic Unit, Trieste, Italy
Received 06 November 2017, Accepted 09 February 2018
Abstract

Zika virus (ZIKV) is an emergent flavivirus transmitted mainly through Aedes spp. mosquitoes that is posing challenge to healthcare services in countries experiencing an outbreak. Usually ZIKV infection is mild, but in some cases it has been reported to progress into neurological diseases such as microcephaly in infants and Guillain-Barré syndrome (GBS) in adults. GBS is a debilitating autoimmune disorder that affects peripheral nerves. Since ZIKV caused massive outbreaks in South America in the past few years, we aimed to systematically review the literature and perform a meta-analysis to estimate the prevalence of GBS among ZIKV-infected individuals. We searched PubMed and Cochrane databases and selected three studies for a meta-analysis. We estimated the prevalence of ZIKV-associated GBS to be 1.23% (95% CI=1.17–1.29%). Limitations include paucity of data regarding previous flavivirus infections and ZIKV-infection confirmation issues. Our estimate seems to be low, but cannot be ignored, since ZIKV outbreaks affects an overwhelming number of individuals and GBS is a life-threatening debilitating condition, especially in pregnant women. ZIKV infection cases must be closely followed to assure prompt care to reduce the impact of GBS associated-sequelae on the quality of life of those affected.

Keywords
Arboviruses, Zika virus, Guillain-Barré syndrome, Epidemiology, Emergent diseases
Braz J Infect Dis 2018;22:137-41 - Vol. 22 Num.2 DOI: 10.1016/j.bjid.2018.02.005