The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2018;22:142-5 - Vol. 22 Num.2 DOI: 10.1016/j.bjid.2018.01.003
Brief communication
Non-polarized cytokine profile of a long-term non-progressor HIV infected patient
Ana Flávia Pinaa, Vanessa Terezinha Gubert de Matosa,, , Camila Mareti Boninb, Márcia Maria Ferrairo Janini Dal Fabbroc, Inês Aparecida Tozettib
a Universidade Federal do Mato Grosso do Sul, Faculdade de Medicina, Campo Grande, MS, Brazil
b Universidade Federal do Mato Grosso do Sul, Centro de Ciências Biológicas e da Saúde, Campo Grande, MS, Brazil
c Departamento Municipal de Saúde, Campo Grande, MS, Brazil
Received 14 August 2017, Accepted 24 January 2018
Abstract

The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Production of IL-6, IL-10, TNF-α, IFN-γ, and IL-17 was detected; in contrast IL-4 was identified. Host-related factors could help explain such a level of infection control, namely the differentiated modulation of the cellular immune response and a non-polarized cytokine response of the TH1 and TH2 profiles.

Keywords
Interleukins, HIV seropositivity, Disease progression, Antiretroviral therapy
Braz J Infect Dis 2018;22:142-5 - Vol. 22 Num.2 DOI: 10.1016/j.bjid.2018.01.003