The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2013;17:579-91 - Vol. 17 Num.5 DOI: 10.1016/j.bjid.2013.03.004
Review article
Modulation of cerebral malaria by curcumin as an adjunctive therapy
Kunal Jain1,, , Sumeet Sood1, K. Gowthamarajan
Department of Pharmaceutics, J.S.S. College of Pharmacy, Udhagamandalam, Tamilnadu 643001, India
Received 12 January 2013, Accepted 21 March 2013
Abstract

Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually. The current therapy is inadequate in terms of reducing mortality or post-treatment symptoms such as neurological and cognitive deficits. The pathophysiology of cerebral malaria is quite complex and offers a variety of targets which remain to be exploited for better therapeutic outcome. The present review discusses on the pathophysiology of cerebral malaria with particular emphasis on scope and promises of curcumin as an adjunctive therapy to improve survival and overcome neurological deficits.

Keywords
Cerebral malaria, Curcumin, Adjunctive, Cognitive deficit
Braz J Infect Dis 2013;17:579-91 - Vol. 17 Num.5 DOI: 10.1016/j.bjid.2013.03.004