The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2017;21:255-62 - Vol. 21 Num.3 DOI: 10.1016/j.bjid.2016.12.008
Original article
Effects of statins on the development of sepsis and organ dysfunction in hospitalized older patients in China
Qifeng Gui, Yunmei Yang, , Jiajia Zhang
Zhejiang University, First Affiliated Hospital School of Medicine, Department of Geriatrics, Hangzhou, China
Received 09 August 2016, Accepted 16 December 2016
Abstract

This study aimed to evaluate the protective role of statins on the development of sepsis and infection-related organ dysfunction and mortality in a hospitalized older Chinese population with bacterial infections. In this retrospective cohort study, 257 older patients with bacterial infection were divided into two groups: a statin group, those who had received statin therapy for ≥1 month before admission and continued receiving statin during hospitalization; and a non-statin group, those who had never received statin or used statin for <1 month prior to admission. A multivariate logistic regression analysis was performed to identify risk and protective factors for severe sepsis. A significantly lower incidence of organ dysfunction was found in the statin group, as compared with the non-statin group (13.3% vs 31.1%, respectively; p=0.002), corresponding to adjusted rates ratio of 0.32 (95% confidence interval [CI], 0.13–0.75; p=0.009). No significant difference was found between statin and non-statin groups in 30-day sepsis-related mortality (4.4% vs 10.2%, respectively; p=0.109), incidence of intensive care unit admission (13.3% vs 16.8%, respectively; p=0.469), or length of hospital stay (20.5 vs 25.9 days, respectively; p=0.61). Statins significantly reduced the development of sepsis and infection-related organ dysfunction in hospitalized older Chinese patients but did not reduce 30-day mortality, ICU admission incidence, or length of hospital stay.

Keywords
Mortality, Organ dysfunction, Older adults, Sepsis, Statins
Braz J Infect Dis 2017;21:255-62 - Vol. 21 Num.3 DOI: 10.1016/j.bjid.2016.12.008