The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2017;21:317-24 - Vol. 21 Num.3 DOI: 10.1016/j.bjid.2017.01.005
Original article
A systematic review of East African-Indian family of Mycobacterium tuberculosis in Brazil
Tonya Azevedo Duartea,, , Joilda Silva Neryb, Neio Boechatc, Susan Martins Pereirab, Vera Simonsend, Martha Oliveirac,e,f, Maria Gabriela Miranda Gomesg,h,i, Carlos Penha-Gonçalvesj, Mauricio Lima Barretob,k, Theolis Barbosae,k,l,,
a Universidade Federal da Bahia, Instituto de Ciências da Saúde, Salvador, BA, Brazil
b Universidade Federal da Bahia, Instituto de Saúde Coletiva, Salvador, BA, Brazil
c Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
d Instituto Adolfo Lutz, São Paulo, SP, Brazil
e Brazilian Network for Research in Tuberculosis – REDE TB, Rio de Janeiro, RJ, Brazil
f Fundação Oswaldo Cruz, Centro de Desenvolvimento de Tecnologia em Saúde, Rio de Janeiro, RJ, Brazil
g Liverpool School of Tropical Medicine, Liverpool, United Kingdom
h Universidade do Porto,Centro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO-InBIO), Porto, Portugal
i Universidade de São Paulo, Instituto de Matemática e Estatística, São Paulo, SP, Brazil
j Instituto Gulbenkian de Ciências, Oeiras, Portugal
k Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, BA, Brazil
l Universidade Federal da Bahia, Programa de Pós-graduação Strictu Sensu em Patologia, Salvador, BA, Brazil
Received 18 November 2016, Accepted 10 January 2017

The Mycobacterium tuberculosis East African-Indian (EAI) spoligotyping family (belonging to lineage 1, Indo-Oceanic, defined by the region of deletion RD239) is distributed worldwide, but is more prevalent in Southeast Asia, India, and East Africa. Studies in Latin America have rarely identified EAI. In this study, we describe the occurrence of the EAI family in Brazil.


EAI was identified in a systematic literature review of genetic diversity studies pertaining to M. tuberculosis in Brazil, as well as in a survey conducted in Salvador, Bahia, located in the northeastern region of this country.


The EAI6-BGD1 spoligotyping family and the EAI5 Spoligotype International Type (SIT) 1983 clade were the most frequently reported, with wide distribution of this particular clade described in Brazil. The distribution of other EAI spoligotyping patterns with broader worldwide distribution was restricted to the southeastern region of the country.


EAI may be endemic at a low frequency in Brazil, with some clades indicating increased fitness with respect to this population.

Mycobacterium tuberculosis, Phylogeography, Genotyping, Epidemiology
Braz J Infect Dis 2017;21:317-24 - Vol. 21 Num.3 DOI: 10.1016/j.bjid.2017.01.005